By Errol C Friedberg
With a Foreword by way of Sydney Brenner (Nobel laureate in body structure or drugs, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from delivery, in 1926, to the current, with detailed emphasis on his huge, immense clinical contributions, together with being the 1st to increase expertise that resulted in gene cloning technology. In 1980, Berg got a Nobel Prize in chemistry for this work.
In addition to his contributions within the learn laboratory, Berg orchestrated and oversaw a historical assembly at Asilomar, California that founded on a threatening controversy surrounding the belief via a few of the destructive strength of recombinant DNA know-how. This assembly did a lot to prevent this controversy and to install position the law of recombinant DNA paintings, therefore placing fears to rest.
The recombinant DNA controversy used to be a historical end result of the invention of gene cloning. particularly, it represented a paramount instance of clinical foresight and due diligence by way of the clinical neighborhood, instead of by means of regulatory entities within the usa and plenty of different nations. the final word recognition of gene/DNA cloning resulted in a brand new period of recent biology that prospers to the present.
This e-book is aimed basically at scientists and people in education. The booklet strives to easily offer details for the overall reader, yet isn't particularly adapted for a common examining audience.
While many books hide the recombinant DNA controversy, none have satisfactorily addressed this old interval and are frequently contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written by means of non-scientists. This biography of Paul Berg presents entry to various archived letters and records at Stanford college now not formerly addressed, and to the chronology of occasions as recalled and documented via him, in addition to different key personalities, lots of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and international struggle II
- Western Reserve University
- Part II:
- Washington college, St. Louis
- Discovering move RNA
- Stanford collage — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a big Breakthrough
- EcoRI restrict Endonuclease — a big Breakthrough
- “Coincidence is the note We Use after we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An ancient assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon examine Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a distinct aspect of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage concerns — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in existence sciences, drugs and chemistry and lay public.
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